|
KMID : 1134820210500030246
|
|
Journal of the Korean Society of Food Science and Nutrition
2021 Volume.50 No. 3 p.246 ~ p.253
|
|
|
Isoscopoletin Inhibits U46619-Induced Platelet Aggregation by Regulating PI3K/MAPK Pathway
|
|
Park Chang-Eun
Lee Dong-Ha
|
|
|
Abstract
|
|
|
|
When blood vessels are damaged, platelet activation and aggregation reactions are essential for the hemostasis process. On the other hand, abnormal or excessive platelet aggregation can cause cardiovascular disease. Therefore, it is important to find a substance that can inhibit platelet aggregation for the prevention and treatment of cardiovascular disease. This study examined the effects of isoscopoletin on U46619-induced human platelet aggregation and the effect on TXA2 production and granule secretion, including ATP and serotonin, which are the major controls. Furthermore, this study examined the effects of isoscopoletin on the regulation of PI3K/Akt and MAPK, which are phosphoproteins that act in the signaling process in platelet aggregation. As a result, isoscopoletin inhibited the phosphorylation of PI3K, Akt, and MAPK, which dose-dependently inhibited platelet aggregation via TXA2 production and decreased intracellular granule secretion, including ATP and serotonin. This paper proposes isoscopoletin as an antiplatelet substance that regulates the phosphorylation of PI3K/Akt and MAPK, which is valuable as a prophylactic and therapeutic agent for cardiovascular diseases derived from platelets.
|
|
|
KEYWORD
|
|
|
isoscopoletin, platelet aggregation, PI3K/Akt, granule secretion
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|